Inspired by tradition. Backed by science.

Notable products are formulated with cutting-edge natural ingredients that have been studied scientifically and often have a rich history of use in Ayurvedic or Traditional Chinese practices. We select these ingredients only after performing a rigorous meta-analysis of the scientific data in collaboration with industry scientists. Our evidence-backed dietary supplement formulations are designed to exert acute effects and work quickly, sometimes in minutes or hours, with additional benefits accruing in the following days.

Notable is proud to adhere to the most stringent quality control standards. Our products are manufactured in a state-of-the-art facility in the United States that is both NSF/cGMP certified and has been inspected by the FDA. Each batch of Notable products undergoes a rigorous biochemical analysis to ensure purity, potency, and absence of contaminants. When you choose Notable, you can trust that you're getting the highest quality, science-backed products on the market.

Ingredients & Studies


Sabroxy® is a standardized extract prepared from the dried bark of the Indian trumpet tree (Oroxylum indicum) and contains a minimum of 10% Oroxylin A. Sabroxy has been shown to significantly enhance motivation & focus in human studies. This may be due to Oroxylin A’s ability to inhibit dopamine reuptake, leading to greater concentrations of dopamine in the brain. Oroxylin A may also increase brain-derived neurotrophic factor (BDNF) in the brain, which supports neurogenesis, protects against neurotoxicity, & promotes memory. In addition to its powerful benefits, Sabroxy can also help balance inflammation levels, support skin health, and regulate the immune system.

Relevant studies

Chen et al. Biochemical Pharmacology. 2022

Sajeev et al. Biomolecules. 2022

Wu et al. Frontiers in Pharmacology. 2022

Lopresti et al. Frontiers in Aging Neuroscience. 2021

Pondugula et al. Natural Product Communications. 2021

Pondugula et al. Plos One. 2021

Lu et al. Phytotherapy Research. 2016

Siddiqui et al. Journal of Research and Opinion. 2012

Dev et al. Pharmacognosy Journal. 2010

Kim et al. Neurobiology of Learning and Memory. 2007

Polygala Tenuifolia

Polygala Tenuifolia, also known as Yuan zhi, is an herb from traditional Chinese practices. Recently, Polygala Tenuifolia has become the subject of academic & scientific research due to its nootropic effects. Polygala Tenufolia supports motivation & focus by both inhibiting monoamine reuptake & inhibiting monoamine oxidase. This may increase concentrations of dopamine, norepinephrine, & serotonin in the brain. Polygala also supports memory by inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine, a neurotransmitter associated with learning & memory. Polygala also may increase BDNF & nerve growth factor (NGF) expression which further promotes optimal memory and contributes to Polygala’s neurogenic & neuroprotective effects.

Relevant studies

Jiang et al. Journal of Ethnopharmacology. 2021

Deng et al. Pharmaceutical Biology. 2020

Jin et al. European Neuropsychopharmacology. 2015

Jin et al. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2014

Li et al. Evidence-Based Complementary and Alternative Medicine. 2014

Chen et al. Evidence-Based Complementary and Alternative Medicine. 2011

Hu et al. Journal of Pharmacy and Pharmacology. 2011

Sun et al. Journal of Southern Medical University. 2009

Hu et al. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2009

Shin et al. Journal of Neuroscience Research. 2008

Park et al. Journal of Neuroscience Research. 2002


enxtra® is an award-winning proprietary extract of Thai ginger (Alpinia galanga) that has been proven in human studies to quickly improve mental alertness & attention. Specifically, enXtra® increases dopamine levels by inhibiting dopamine reuptake. enXtra® also strategically modulates cholinergic & adenosine signaling to support memory & reduce fatigue. In all clinical studies, enXtra® has been proven safe with no impact on heart rate, blood pressure, or sleep.

Relevant studies

Shanmugasundaram. Journal of Complementary and Integrative Medicine. 2022

Srivastava et al. Journal of the American College of Nutrition. 2021

Sivanandan et al. Advances in Biological Chemistry. 2018

Srivastava. Open Access Journal of Clinical Trials. 2018

Srivastava et al. Journal of the American College of Nutrition. 2017

Srivastava et al. Journal of the American College of Nutrition. 2017

Saha et al. Indian Journal of Experimental Biology. 2013

Kaushik et al. Journal of Chinese Integrative Medicine. 2011

Singh et al. Journal of Ethnopharmacology. 2011

Ginkgo Biloba

Renowned as one of the top herbs for brain health Ginkgo (Ginkgo biloba) synergizes with the dopamine-boosting ingredients in Notable Focus by increasing levels of acetylcholine & norepinephrine. Research shows that Ginkgo inhibits the acetylcholinesterase enzyme and norepinephrine reuptake to support aspects of memory & attention respectively. In addition, Ginkgo is packed with neuroprotective nutrients that protect the brain by reducing oxidative stress & enhancing cerebral blood flow.

Relevant studies

Liu et al. Frontiers in Pharmacology. 2020

Ude et al. Clinical Pharmacokinetics. 2013

Kehr et al. International Psychogeriatrics. 2012

Masahyekh et al. Functional Neuroradiology. 2010

Fehske et al. Pharmacological Research. 2009

Ahlemeyer et al. Cellular and Molecular Life Sciences. 2003

Das et al. Pharmacology Biochemistry and Behavior. 2002


L-Theanine is one of the main active constituents found in green tea. L-Theanine may promote attention & relaxation by supporting alpha-1 wave generation. L-Theanine also may regulate stress & jitters by promoting GABAergic neurotransmission & blocking glutamate receptors. In addition to these mechanisms, L-Theanine may also increase BDNF expression which contributes to its neuroprotective benefits.

Relevant studies

Williams et al. Plant Foods for Human Nutrition. 2020

Hidese et al. Nutrients. 2019

Tian et al. Brain Research. 2013

Wakabayashi et al. Psychopharmacology. 2011

Kakuda et al. Pharmacological Research. 2011

Kimura et al. Biological Psychology. 2007

Nathan et al. Journal of Herbal Pharmacotherapy. 2006

Song et al. The Korean Journal of Nutrition. 2003

Song et al. Korean Journal of Family Medicine. 2002

Holding Notable to a higher standard

Rigorous Formulation Process

Notable products are formulated by experts with extensive knowledge of neuropharmacology & herbal ingredients. Our process includes performing a meta-analysis of each ingredient’s existing scientific studies including preclinical & clinical trials. We only select ingredients exhibiting significant efficacy & safety in human studies.

Extensive Biochemical Analysis

For every batch of Notable products, we perform extensive testing to confirm each ingredient’s identity, purity, strength, & composition, as well as for the presence of any contaminants such as heavy metals or pesticides. This includes chemical analysis that goes above and beyond guidelines set by the United States Food & Drug Administration.

State-Of-The-Art Manufacturing Process

We proudly manufacture every Notable product in an FDA-registered, NSF Good Manufacturing Practice (GMP) registered facility in the United States.