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Sabroxy® is a standardized extract prepared from the dried bark of the Indian trumpet tree (Oroxylum indicum) and contains a minimum of 10% Oroxylin A. Sabroxy has been shown to significantly enhance motivation & focus in human studies. This may be due to Oroxylin A’s ability to inhibit dopamine reuptake, leading to greater concentrations of dopamine in the brain. Oroxylin A may also increase brain-derived neurotrophic factor (BDNF) in the brain, which supports neurogenesis, protects against neurotoxicity, & promotes memory. In addition to its powerful benefits, Sabroxy can also help balance inflammation levels, support skin health, and regulate the immune system.

Polygala Tenuifolia, also known as Yuan zhi, is an herb from traditional Chinese practices. Recently, Polygala Tenuifolia has become the subject of academic & scientific research due to its nootropic effects. Polygala Tenufolia supports motivation & focus by both inhibiting monoamine reuptake & inhibiting monoamine oxidase. This may increase concentrations of dopamine, norepinephrine, & serotonin in the brain. Polygala also supports memory by inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine, a neurotransmitter associated with learning & memory. Polygala also may increase BDNF & nerve growth factor (NGF) expression which further promotes optimal memory and contributes to Polygala’s neurogenic & neuroprotective effects.

enxtra® is an award-winning proprietary extract of Thai ginger (Alpinia galanga) that has been proven in human studies to quickly improve mental alertness & attention. Specifically, enXtra® increases dopamine levels by inhibiting dopamine reuptake. enXtra® also strategically modulates cholinergic & adenosine signaling to support memory & reduce fatigue. In all clinical studies, enXtra® has been proven safe with no impact on heart rate, blood pressure, or sleep.

Renowned as one of the top herbs for brain health Ginkgo (Ginkgo biloba) synergizes with the dopamine-boosting ingredients in Notable Focus by increasing levels of acetylcholine & norepinephrine. Research shows that Ginkgo inhibits the acetylcholinesterase enzyme and norepinephrine reuptake to support aspects of memory & attention respectively. In addition, Ginkgo is packed with neuroprotective nutrients that protect the brain by reducing oxidative stress & enhancing cerebral blood flow.

L-Theanine is one of the main active constituents found in green tea. L-Theanine may promote attention & relaxation by supporting alpha-1 wave generation. L-Theanine also may regulate stress & jitters by promoting GABAergic neurotransmission & blocking glutamate receptors. In addition to these mechanisms, L-Theanine may also increase BDNF expression which contributes to its neuroprotective benefits.